Gondo Toshikazu
Affiliate Master
Yamaguchi University
Primary gastric choriocarcinoma associated with adenocarcinoma-A Case Report with Immunohistochemical Study-
The bulletin of the Yamaguchi Medical School Volume 32 Issue 1
Page 11-19
published_at 1985-12
Title
Primary gastric choriocarcinoma associated with adenocarcinoma-A Case Report with Immunohistochemical Study-
Creators
Kamei Toshiaki
Creators
Maeda Junpei
Creators
Kondo Naotsugu
Creators
Hongo Hiroshi
Creators
Yanagihara Teruo
Creators
Nakamura Isao
Creators
Ishihara Tokuhiro
Creators
Okuzono Yoshiko
Creators
Fujihara Shigeyoshi
Source Identifiers
Creator Keywords
choriocarcinoma
adenocarcinoma
stomach
immuoohistochemistry
histogenesis
A case of a 69 year old female with primary gastric choriocarcinoma was presented with spesial reference to histogenesis by using the immunohistochemical tequnique (PAP method). The gastric tumor in this case was histologically diagnosed as choriocarcinoma coexistent with adenocarcinoma. From hormonal standpoint, the diagnosis was confirmed by recognition of high HCG titers in both the serum and tumor. The primary focus of the choriocarcinoma was detected neither in the genitourinary tract nor in the mediastinum in spite of a thorough autopsy. By PAP method tumor cells of choriocarcinoma showed high positive reaction only to anti-HCG antiserum and less positive to anti-HPL and SP1 antisera in contrast to those of uterine choriocarcinoma with high positive reaction to anti-HCG, HPL and SP1 antisera. Tumor cells of adenocarcinoma showed positivity to anti-CEA and anti-AFP antisera by the same method. These results indicate that gastric choriocarcinoma might be functionally defferent from gestational choriocarcinoma. Moreover, tumor cells of adenocarcinomatous lesion have some resemblance to embrynal carcinoma morphologically and immunohistochemically. Therefore, the origin of gastric choriocarcinoma seemed to be morphological retrodifferentiation of tumor cells to embryonal ectoderm such as trophoblastic cells.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1985-12
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部