Effect of Absolute Ethanol Injection into Solid Tumors Estimated by Xe Tumor Blood Flow on a Mouse and a Human

Creators Ebe Kazuyu

Creators Suda Hiroki

Creators Kuramitu Tatuya

Creators Honma Yutaka

Creators Okada Morihisa

Creators Hatanaka Masao

Creators Tanaka Nobuyuki

Creators Suga Kazuyoshi

Creators Sasai Kazuhiko

Creators Tanaka Rikuo

Creators Yokoyama Takashi

Creators Nakanishi Takashi

Creators Nishihara Sadamitsu

Creators Utumi Hiromot

Creators Yamada Norimasa

The tumor blood flow was calculated by Xe clearance curves. Absolute Ethanol injection shuts off the tumor blood flow very powerfully. In the case of a nude mouse, 0.05 ml of absolute ethanol decreased the tumor blood flow to 60% and 0.10 ml of it decreased to 11% markedly. The latter tumor fell and cured 2 weeks later, but the former still grew. In a human, two cases who had mitastatic tumors st the chest walls were treated in the same way. In the first case, 20 ml of it was injected and tumor blood flow was decreased to 27%. In the second case, 25 ml of it was injected and the tumor blood flow was decreased to 2.4%. The enhanced Computed Tomography scans showed massive tumor necrosis occurred a week later in the both cases. The decreased tumor blood flow correlated to the tumor responses to absolete ethanol injections on both a mouse and a human.

[ISSN]0513-1812

[NCID]AA00594272