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Hazama Shoichi

Affiliate Master Yamaguchi University

An invited review following the Soujinkai Young Investigator Award : calreticulin is highly expressed in pancreatic cancer stem-like cells

The bulletin of the Yamaguchi Medical School Volume 67 Issue 3-4 Page 19-23
published_at 2020
A050067000302.pdf
[fulltext] 444 KB
Title
An invited review following the Soujinkai Young Investigator Award : calreticulin is highly expressed in pancreatic cancer stem-like cells
Creators Matsukuma Satoshi
Creators Yoshimura Kiyoshi
Creators Tsunedomi Ryouichi
Creators Hazama Shoichi
Creators Nagano Hiroaki
Source Identifiers
Creator Keywords
pancreatic cancer cancer stem-like cells calreticulin
Pancreatic cancer is an intractable disease with a poor prognosis. Recent research has demonstrated that the resistance of these cancers to conventional treatment, the high rate of local recurrence and distant metastasis may be attributed to a small subset of cells in cancer tissues known as cancer stem-like cells. It is critically important to elucidate the biological properties of cancer stem-like cells and develop strategies targeting these cells to overcome pancreatic cancers. We established a pancreatic cancer stem-like cell induction method from a cancer cell line and identified calreticulin as a highly expressed protein on the surface of these cells using proteomics and flow cytometry. Notably, we demonstrated that calreticulin was expressed on cells with high ATP-binding cassette transporter activity known to mediate drug efflux and related to poor outcomes in pancreatic cancer patients who underwent curative resection. Calreticulin exposure in cancer stem-like cells could be regulated by oxidative stress via hypoxia-inducible factors which induce the expression of CD47 and PD-L1 to evade the immune-surveillance of these cells. Further investigations on calreticulin expression in pancreatic cancer stem-like cells could elucidate the pathophysiology of these cells, leading to the development of novel therapy.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2020
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学) 医学部