Scanning Electron Microscopy on the Spiral Direction of the Cell Bodies of Some Spirochetes

Creators Yoshii Zensaku

Creators Nisimune Takahiro

Creators Tanaka Shuhei

Creators Konishi Hisanori

Creators Harada Tomoyasu

Creators Kimoto Mitsuaki

Creators Kobayashi Masaru

Creators Maeda Hidezo

Creators Watanabe Kazuhiko

The effects of intravenously administered lidocaine on the cerebral cortical energy state and glycolytic metabolism were studied in rats. Rats were divided into five groups according to EEG patterns, I.E., control, desynchronized, synchronized, seizure (1 minduration) and recovery groups. With lidocaine infusion (0.75mg/min), there were no significant changes from the control group in the cerabral energy state except for a modest increase in phosphocreatine in the seizre group and a small decrease in ADP in the non-seizure groups. The cerebral energy charge remained unchanged. Lactate and pyruvate significantly decreased in the non-seizure groups. It is concluded that neither a non-seizure nor seizure dose of lidocaine caused any reduction in the cerebral energy charge. There was no evidence of increased anaerobic metabolism in the cerebral cortex during lidocaine-induced seizures.

[ISSN]0513-1812

[NCID]AA00594272