Larvicidal effects of the short-term medication of levamisole hydrochloride to developing stages of Dirofilaria immitis in infected dogs

犬糸状虫幼虫に対するLevamisole短期投与の殺滅効果

Larvicidal effects of the short-term medication of levamisole hydrochloride to developing stages of Dirofilaria immitis in infected dogs

Creators Hayasaki Mineo

Creators 中垣 和英

Creators 大石 勇

Larvicidal effects of levamisole hydrochloride to developing stages of Dirofilaria immitis were evaluated in the experimentally infected dogs. Four groups of dogs were administered 1, 30, 60 and 90 days after infection with 5 mg/kg, t.i.d. (15mg/kg/day) of levamisole hydrochloride for 5 days (Table 1). In two experimental groups medicated at 60 or 90 days postinfection, the drug showed complete or least certain prophylactic effects against D. immitis infection. On the other hand, in the other two experimental groups medicated at 1or 30 days postinfection, relatively low larvicidal effects were seen. To the contrary, mean infection rate in control dog group was 35.7%. The worm development in these two medicated groups was significantly depressed in comparison with those from control group (Table 2). These data suggested that the complete prophylactic effects may be obtained by a few courses of the present dosage of levamisole hydrochloride from the 2nd month after the biginning of infectious season until the 2nd month after the end of it at intervals of two months throughout the season.

[ISSN]0021-5171

[NCID]AN00051494

[isVersionOf] Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis [URI]http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2010010511