Effect of an Angiotensin-Converting Enzyme Inhibitor on Smooth Muscle Myosin Isoforms in Afferent Arterioles from Spontaneously Hypertensive Rats
The bulletin of the Yamaguchi Medical School Volume 43 Issue 3-4
Page 99-106
published_at 1996-12
Title
Effect of an Angiotensin-Converting Enzyme Inhibitor on Smooth Muscle Myosin Isoforms in Afferent Arterioles from Spontaneously Hypertensive Rats
Creators
Kawata Yasunobu
Source Identifiers
Creator Keywords
Smooth muscle myosin heavy chain isoforms
Spontaneously hypertensive rat
Afferent arteriole
ACE inhibitor
I used immunohistchemical analysis to examine the expression of smooth muscle myosin heavy chain (MHC) isoforms (SM1 and SM2) in renal arterioles from 20- week-old Wister Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). I also examined the effect of an angiotensin-converting enzyme inhibitor, enalapril, on the expression of MHC isoforms in renal afferent arterioles from SHR. SM1 was expressed in both afferent and efferent arterioles from WKY and SHR, but much less expressed in efferent arterioles compared with afferent arterioles. On the other hand, SM2 was only expressed in afferent arterioles, and was less expressed in vehicle SHR than WKY. The expression of SM1 and SM2 in afferent arterioles from enalapril-treated SHR for 6 weeks and WKY were more increased than those from vehicle SHR (WKY vs vehicle SHR
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1996-12
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部