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Hepatitis B surface antigen variants detected in a hepatitis B virus carrier with concurrent HBsAg and anti-HBs

山口医学 Volume 49 Issue 5 Page 497-501
published_at 2000-10-31
B030049000505.pdf
[fulltext] 351 KB
Title
HBs抗原変異株が検出されたHBs抗原・抗体共存のB型肝炎ウイルスキャリアーの1例
Hepatitis B surface antigen variants detected in a hepatitis B virus carrier with concurrent HBsAg and anti-HBs
Creators Nishina Sohji
Creators Hino Keisuke
Creators Katoh Yoshiharu
Creators Okita Kiwamu
Source Identifiers
Creator Keywords
HBs抗原 HBs抗原変異株 B型肝炎
Hepatitis B surface antigen(HBsAg) is neutralized by anti-HBsAg antibody(anti-HBs). However, HBsAg variants can persist in the spite of the presence of anti-HBs. Hepatitis B vaccination or hepatitis B immunoglobulin therapy is one of the situations that can drive the selection of variants. Thus selection of most variants is likely to be immune-driven. On the other hand, there are also naturally occurring variants, but the mechanism of their emergence has not been clarified. Here we descride a hepatitis B virus(HBV) carrier with concurrent HBsAg and anti-HBs in whom several amino acid substitution was found in the major hydrophilic region of HBsAg. This case provides a discussion that concurrence of HBsAg and anti-HBs may drive selection of HBsAg variants.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2000-10-31
Rights
本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002774009/
Schools 医学部