Signal transduction of ischemic heart
山口医学 Volume 50 Issue 1
Page 563-568
published_at 2001-02-28
Title
心筋虚血における細胞内シグナル伝達
Signal transduction of ischemic heart
Source Identifiers
Creator Keywords
心臓
虚血
MAPK
PKC
オーファン受容体
In response to ischemia and reperfusion, mammalian cells induce various pathways that lead to cell death and organ dysfunction. Although PKC isoforms are known to be differentially expressed in various cells and regulated by distinct activators, the role of PKC isoforms in ischemic heart have been poorly elucidated. PKC α, δ, and ε isoforms translocate to distinct organelle during ischemia. PKC ζ, an atypical PKC isoforms, which is activated by phosphoinositide 3-kinase during ischemia, induces MAPK activation through MEK in the nucleus during reperfusion, and PKC ζ/MAPK pathway protects cells from apoptosis during reperfusion through α-enolase expression.
Languages
jpn
Resource Type
journal article
Publishers
山口大学医学会
Date Issued
2001-02-28
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools
医学部