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A Case of Refractory Non-Hodgkin's Lymphoma Which Had Responded to Continuous Infusion Therapy with Carboplatin and Etoposide

山口医学 Volume 43 Issue 4 Page 231-236
published_at 1994-08
Title
カルボプラチン、エトポジド接続点滴療法が著効を示した非ホジキンリンパ腫の一例
A Case of Refractory Non-Hodgkin's Lymphoma Which Had Responded to Continuous Infusion Therapy with Carboplatin and Etoposide
Creators Takeuchi Yasuo
Creators Ayame Hideo
Creators Nishimura Manabu
Creators Egami Tetuhiro
Creators Takahashi Mutuo
Source Identifiers
Creator Keywords
悪性リンパ腫 カルボプラチン(Carboplatin) エトポシド(Etoposido) 化学療法
A 47 year- old female with non-Hodgkin's lymphoma (primary gastric With non-Hodgkin's cell type, stage IVb) was treated with continuous infusion therapy using Carboplatn (CBDCA) and Etoposide (VP-16) , after her disease had failed to respond to initial induction chemotherapies consisting of Cyclophospharnide, Doxorubicin, Etoposide, Ara-C, Pepleomycin, Vindesine and Methotrexate or aiso consisting of Doxorubicin, Vandesine and BHAC. No gastrointestinal symptoms nor renal toxicity appeared during continuous infusion therapy. Mild hepatic dysfunction was shown but temporal. In general , myelosuppression is often major dose-limiting factor, but it was mild and well tolerated in this therapy as compared wiith those of standard regimens. As anti-tumor effects, decreased lactate dehydrogenase (LDH) value and reduced tumor burden which was shown on abdominal computer tomograph or upper gastrointestinal barium radiography were observed. Ameliorated performance status was also seen after treatment. It is concluded that this chemotherapy regimen was worthy to be challenged for refractory cases which were not respondent to conventional chemotherapy schedules.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1994-08
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部