Immunological response of dogs to Dirofilaria immitis infection

犬糸状虫寄生犬における免疫応答について

Immunological response of dogs to Dirofilaria immitis infection

Creators Hayasaki Mineo

Creators Nakagaki Kazuhide

Creators Kobayashi Shigeo

Creators Ohishi Isamu

The immunological responses of dogs infected with Dirofilaria immitis were studied by macrophage migration inhibition (MI) test (indirect method), indirect hemagglutination (IHA) test and passive cutaneous anaphylaxis reaction. Both 13 non-infected dogs and 20 naturally infected dogs were negative for MI test, when examined with antigens prepared from adult worms and intrauterine microfilariae. Three dogs experimentally infected with D. immitis (98 to 121 infective larvae) and 2 non-infected controls were monitored for the kinetics of immunological responses during the course of infection. In infected dogs, both IHA and reaginic antibody productions were demonstrated throughout prepatent and patent periods of the infection. It seems likely that the marked production of these antibodies was associated with the timing of fourth larval molt and the occurence of microfilaremia. Nevertheless, the MI tests were negative for these dogs throughout the prepatent period of the infection.

[ISSN]0021-5295

[NCID]AN00191788

[isVersionOf] [URI]http://www.jstage.jst.go.jp/browse/jvms/-char/ja

[isVersionOf] Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis [URI]http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2010010511