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Sequential administration of sclerostin antibody and parathyroid hormone differentially modulates fracture healing in a murine tibial osteotomy model

PLoS One Volume 21 Issue 7
published_at 2026-07-17
journal.pone.0354181.pdf
[fulltext] 1.51 MB
Supplemental Data : https://public.oa.kenkyu.yamaguchi-u.ac.jp/f4196809-dee6-46be-8264-0dee1cf66c42
Title
Sequential administration of sclerostin antibody and parathyroid hormone differentially modulates fracture healing in a murine tibial osteotomy model
Creators Mihara Atsushi
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Yukata Kiminori
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Nishida Norihiro
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Seto Tetsuya
Creators Iwanaga Ryuta
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Fujii Kenzo
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Uehara Kazuya
Creators Saeki Yuji
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Ohgi Junji
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Tsuji Shunya
[e_rad]80898370 1000080898370
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Asagiri Masataka
[e_rad]20372435 1000020372435
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Sakai Takashi
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Source Identifiers [EISSN] 1932-6203
Languages eng
Resource Type journal article
Publishers PLOS
Date Issued 2026-07-17
Rights
© 2026 Mihara et al.()
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.()
Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
File Version Version of Record
Access Rights open access
Relations
[isIdenticalTo] 10.1371/journal.pone.0354181
[isSupplementedBy] [URI]https://public.oa.kenkyu.yamaguchi-u.ac.jp/f4196809-dee6-46be-8264-0dee1cf66c42
Funding Refs
Japan Society for the Promotion of Science [crossref_funder]https://doi.org/10.13039/501100001691
Award 濃縮骨髄液を用いた良性骨腫瘍切除後の再建法の開発 21K16657
Funding Refs
Japan Society for the Promotion of Science [crossref_funder]https://doi.org/10.13039/501100001691
Award Interaction of PTH and Wnt/beta-catenin signaling on impaired fracture healing with aging 24K12417