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An invited review following the Soujinkai Young Investigator Award : ryanodine receptor bound calmodulin as a novel therapeutic target of arrhythmias and heart failure

The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 Page 1-6
published_at 2019
A050066000101.pdf
[fulltext] 1.09 MB
Title
An invited review following the Soujinkai Young Investigator Award : ryanodine receptor bound calmodulin as a novel therapeutic target of arrhythmias and heart failure
Creators Kato Takayoshi
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Yamamoto Takeshi
Creators Kobayashi Shigeki
Creators Yano Masafumi
Source Identifiers
Creator Keywords
heart failure lethal arrhythmia cardiac ryanodine receptor calmodulin
Life-threatening situations that can arise in patients with heart failure are widely recognized in clinical cardiology. This occasionally results from ventricular arrhythmias and hence the management of lethal arrhythmias is now one of the most important issues in the treatment of heart failure. In the failing cardiomyocytes, an abnormal regulation of intracellular calcium (Ca^{2+}) handling by a Ca^{2+} release channel of the sarcoplasmic reticulum (SR), so-called ryanodine receptor (RyR2), is known to play an important role in the mechanism underlying cardiac arrhythmias. On the other hand, in catecholaminergic polymorphic ventricular tachycardia (CPVT), mutation- linked defective channel gating of the RyR2 is also known as a major pathogenic mechanism underlying fatal arrhythmias. The knowledge gained from these studies upon the RyR2 and its modulatory proteins, such as calmodulin (CaM), may lead to the development of a new pharmacological or genetic strategy for the treatment of heart failure and cardiac arrhythmias. In this review, we focused on the role of CaM on the regulation of the channel gating of the RyR2 in the pathogenesis of heart failure and fatal arrhythmias, and discuss the possibility of developing a novel therapeutic strategy targeting the RyR2.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2019
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学)