An invited review following the Soujinkai Young Investigator Award : ryanodine receptor bound calmodulin as a novel therapeutic target of arrhythmias and heart failure
The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2
Page 1-6
published_at 2019
Title
An invited review following the Soujinkai Young Investigator Award : ryanodine receptor bound calmodulin as a novel therapeutic target of arrhythmias and heart failure
Source Identifiers
Creator Keywords
heart failure
lethal arrhythmia
cardiac ryanodine receptor
calmodulin
Life-threatening situations that can arise in patients with heart failure are widely recognized in clinical cardiology. This occasionally results from ventricular arrhythmias and hence the management of lethal arrhythmias is now one of the most important issues in the treatment of heart failure. In the failing cardiomyocytes, an abnormal regulation of intracellular calcium (Ca^{2+}) handling by a Ca^{2+} release channel of the sarcoplasmic reticulum (SR), so-called ryanodine receptor (RyR2), is known to play an important role in the mechanism underlying cardiac arrhythmias. On the other hand, in catecholaminergic polymorphic ventricular tachycardia (CPVT), mutation- linked defective channel gating of the RyR2 is also known as a major pathogenic mechanism underlying fatal arrhythmias. The knowledge gained from these studies upon the RyR2 and its modulatory proteins, such as calmodulin (CaM), may lead to the development of a new pharmacological or genetic strategy for the treatment of heart failure and cardiac arrhythmias. In this review, we focused on the role of CaM on the regulation of the channel gating of the RyR2 in the pathogenesis of heart failure and fatal arrhythmias, and discuss the possibility of developing a novel therapeutic strategy targeting the RyR2.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2019
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
大学院医学系研究科(医学)