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Ultrastructural Investigation of Neuronal Damage induced by Interstitial Radiofrequency Hyperthermia in Adult Dogs

The bulletin of the Yamaguchi Medical School Volume 41 Issue 3-4 Page 143-148
published_at 1994-12
A020041000310.pdf
[fulltext] 1.93 MB
Title
Ultrastructural Investigation of Neuronal Damage induced by Interstitial Radiofrequency Hyperthermia in Adult Dogs
Creators Tsuchida Eiji
Creators Ikeda Norio
Creators Akimura Tatuo
Creators Kameda Hideki
Creators Ito Haruhide
Creators Matsuda Tadayoshi
Source Identifiers
A study was conducted using electron microscopy to investigate hyperthermia-induced damage to neurons and myelinated nerve tracts in order to determine the thermal threshold. Twenty adult dogs were used. After parietal craniectomy, four electrode meedles connected to a Thermotron-RF8 for interstitial 8-MHz radiofrequency hyperthermia were inserted in a 1 cm square pattern and placed at a depth of 1.5 cm from the brain surface. One thermocouple microprobe was set in the center of the square formed by the electrodes. One hour after heating for 15, 30, 45 and 60 minutes with set temperatures of 42℃ and 43℃, the animal's a brain was removed and the ultrastructural investigation was performed. The findings suggested that the normal brain adjacent to a tumor in vivo would be damaged irreversibly by a large thermal dose, and that neurons showed ultrastructura changes such as swollen or empty of mitochondria and central chromatolysis even after small and moderate thermal doses.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1994-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部