Regression of abdominal aortic aneurysms by pharmacological inhibition of c-Jun N-terminal kinase
The bulletin of the Yamaguchi Medical School Volume 54 Issue 3-4
Page 29-31
published_at 2007
Title
Regression of abdominal aortic aneurysms by pharmacological inhibition of c-Jun N-terminal kinase
Creators
Aoki Hiroki
Source Identifiers
Creator Keywords
abdominal aortic aneurysm
c-Jun N-terminal kinase
pharmacological therapy
Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation and proteolytic degradation of the extracellular matrix (ECM). Recently, we identified c-Jun N-terminal kinase (JNK) as a key molecule in the pathogenesis of AAA. Human AAA tissue showed a high level of active JNK. In in vitro studies, JNK not only activated the expression of ECM-degrading enzymes, but also suppressed the expression of enzymes for ECM biosynthesis. Finally, pharmacological inhibition of JNK not only prevented the development of AAA but also caused the regression of established AAA in mouse models. Thus, pharmacological inhibition of JNK may provide a novel therapeutic option for treatment of human AAA.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2007
File Version
Version of Record
Access Rights
open access
Relations
[isVersionOf]
[URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools
医学部