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Regression of abdominal aortic aneurysms by pharmacological inhibition of c-Jun N-terminal kinase

The bulletin of the Yamaguchi Medical School Volume 54 Issue 3-4 Page 29-31
published_at 2007
A050054000302.pdf
[fulltext] 466 KB
Title
Regression of abdominal aortic aneurysms by pharmacological inhibition of c-Jun N-terminal kinase
Creators Yoshimura Koichi
Creators Aoki Hiroki
Creators Ikeda Yasuhiro
Creators Furutani Akira
Creators Hamano Kimikazu
Creators Matsuzaki Masunori
Source Identifiers
Creator Keywords
abdominal aortic aneurysm c-Jun N-terminal kinase pharmacological therapy
Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation and proteolytic degradation of the extracellular matrix (ECM). Recently, we identified c-Jun N-terminal kinase (JNK) as a key molecule in the pathogenesis of AAA. Human AAA tissue showed a high level of active JNK. In in vitro studies, JNK not only activated the expression of ECM-degrading enzymes, but also suppressed the expression of enzymes for ECM biosynthesis. Finally, pharmacological inhibition of JNK not only prevented the development of AAA but also caused the regression of established AAA in mouse models. Thus, pharmacological inhibition of JNK may provide a novel therapeutic option for treatment of human AAA.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2007
File Version Version of Record
Access Rights open access
Relations
[isVersionOf] [URI]http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
Schools 医学部