High Pressure as a Mechanical Stress and Mitogen-Activated Protein Kinase Activation in Glomerular Diseases

The bulletin of the Yamaguchi Medical School Volume 46 Issue 3-4 Page 71-77

published_at 1999-12

A020046000302.pdf

[fulltext] 700 KB

Title

High Pressure as a Mechanical Stress and Mitogen-Activated Protein Kinase Activation in Glomerular Diseases

Creators Kawata Yasunobu

Source Identifiers

Creator Keywords

mechanical stress MAP kinase mesangial cell

Progressive renal diseases lead to prolonged glomerular hypertension, which acts as a mechanical stress to mesangial cells and induced the proliferation of mesangial cells. In mesangial cell proliferation, various growth factors and mitogemic stimuli are known to induce the activation of mitogen-activated protein kinase (MAPK), whish serves as an important regulator of transcriptional activity with cell proliferation. Here I review the relationship of glomerular hypertension as a mechanical stress and MAPK activation, which induces glomerular sclerosis through proliferation in mesangial cells.

Subjects

医学 ( Other)

Languages eng

Resource Type departmental bulletin paper

Publishers Yamaguchi University Graduate School of Medicine

Date Issued 1999-12

File Version Version of Record

Access Rights open access

Relations

[ISSN]0513-1812

[NCID]AA00594272

Schools 医学部