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On the Separation and Identification of Sulfonamides by the Thin-Layer Chromatography and the Detection of Sulfa Drug in the Cadaveric Blood

The bulletin of the Yamaguchi Medical School Volume 17 Issue 3-4 Page 179-189
published_at 1970-12
A020017000301.pdf
[fulltext] 1.3 MB
Title
On the Separation and Identification of Sulfonamides by the Thin-Layer Chromatography and the Detection of Sulfa Drug in the Cadaveric Blood
Creators Furuno Junji
Creators Sugawara Norisuke
Creators Kan Takeshi
Source Identifiers
The autors have described the separation and identification of seven kinds of sulfonamides by means of the thin-layer chromatograghy and an example for the detection of sulfamonomethoxine sodium in the cadaveric blood. In the separation of these sulfonamides, the developers of chloroform-methanol system which consist of two or more kinds of polar and non-polar solvents, gave the satisfactory result. All these sulfonamides could be detected even in a very small quantities of 0.1 μg by using p-dimethylaminobenzaldehyde or diazo reagent and the color was very clear. As a result, both reagents would be expected to be available for the detecting reagent in the usual analysis of sulfonamides. From the blood (8 ml) of a man aged 52 who ”Daimeton” injection was intravenously received and suddenly died, sulfamonomethoxine sodium was separated and identified through the analysis coupled with the thin-layer chromatography and ultraviolet absorption spectrophotometry. The quantities of sulfamonomethoxine sodium determined about the remainder of blood extract after the qualititive analysis was approximately 3.0 mg.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1970-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部