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Hyperplasia of Brunner's glands

The bulletin of the Yamaguchi Medical School Volume 26 Issue 1-2 Page 43-48
published_at 1979-06
A020026000106.pdf
[fulltext] 1.41 MB
Title
Hyperplasia of Brunner's glands
Creators Sasaki Kohsuke
Creators Ogino Tetsuro
Creators Sasai Kazuhiko
Creators Suemori Tagao
Creators Emoto Isao
Creators Takahashi Manabu
Source Identifiers
Creator Keywords
duodenal polyp tumor of the duodenum hamartoma of the dumodenum duodenal adenoma
An unstable hemoglobin, Hb Iwata, F8 (α87) His → Arg, was discovered during a screening program for hemoglobin anomalies in the newborns. Studies of the family members of the proband revealed the father and the paternal grandmother to also carry the abnormal hemoglobin. None of the carriers of the abnormal hemoglobin manifested clinical symptoms, probably because Hb Iwata migrated between Hb A and A_2 in starch gen electrophoresis (pH 8.6), and was isolated by DE-52 column chromatography. Analysis of the amino acid composition of tryptic peptides from the α chain of Hb Iwata demonstrated the substitution of the proximal histidine by arginine. Results of the isopropanol, heat denaturation and Heinz body formation tests indicated instability of Hb Iwata. Hb Iwata rapidly auto-oxidized into semihemichrome and subsequently precipitated. The oxidation also accelerated heme loss, and the heme-depleted Hb Iwata tended to dessociate in reference to stereochemical properties other abnormal hemoglobins with substitution of the proximal or distal histidine.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1979-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部