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Primary Reading Epilepsy

The bulletin of the Yamaguchi Medical School Volume 26 Issue 3-4 Page 123-129
published_at 1979-12
A020026000307.pdf
[fulltext] 855 KB
Title
Primary Reading Epilepsy
Creators Ota Tamio
Creators Mizuki Akio
Creators Kawasawa Syuhei
Creators Nakamura Yoshitsugu
Creators Yamada Michio
Creators Samura Yukiko
Creators Shibata Jiro
Creators Suizu Kazuo
Source Identifiers
Creator Keywords
reading epilepsy EGG CT psychotic state
Phosphorylation of two species of erythrocyte pyruvate kinase (PK, EC 2.7.1.40), PK-R_1 and PK-R_2, was analyzed. The light fraction of younger red cells which has a low PK-R_2/PK-R1 ratio, and the dense fraction of older cells which has a high PK ratio were used as the enzyme source. On phosphorylation in the presence of cyclic AMP, PK of the dense fraction showed a larger amount of ^32P incorporation than that of the light fraction. Most of the radioactivity incorporated was recovered in the L' subunit of PK. The unphosphorylated PK of the dense fraction had a lower affinity for phosphorylated PK of the dense fraction still showed a lower affinity for PEP than that of the light fraction. There results indicate that PK-R_1 and PK-R_2 are controlled by phosphorylation with a decrease of the affinity for PEP. The postsynthetic transformation of PK-R_1 into PK-R_2 is considered as a maturation process or molecular aging of the enzyme which involves protein degradation in erythrocytes.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1979-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部