Primary Reading Epilepsy
The bulletin of the Yamaguchi Medical School Volume 26 Issue 3-4
Page 123-129
published_at 1979-12
Title
Primary Reading Epilepsy
Creators
Ota Tamio
Creators
Mizuki Akio
Creators
Kawasawa Syuhei
Creators
Nakamura Yoshitsugu
Creators
Yamada Michio
Creators
Samura Yukiko
Creators
Shibata Jiro
Creators
Suizu Kazuo
Source Identifiers
Creator Keywords
reading epilepsy
EGG
CT
psychotic state
Phosphorylation of two species of erythrocyte pyruvate kinase (PK, EC 2.7.1.40), PK-R_1 and PK-R_2, was analyzed. The light fraction of younger red cells which has a low PK-R_2/PK-R1 ratio, and the dense fraction of older cells which has a high PK ratio were used as the enzyme source. On phosphorylation in the presence of cyclic AMP, PK of the dense fraction showed a larger amount of ^32P incorporation than that of the light fraction. Most of the radioactivity incorporated was recovered in the L' subunit of PK. The unphosphorylated PK of the dense fraction had a lower affinity for phosphorylated PK of the dense fraction still showed a lower affinity for PEP than that of the light fraction. There results indicate that PK-R_1 and PK-R_2 are controlled by phosphorylation with a decrease of the affinity for PEP. The postsynthetic transformation of PK-R_1 into PK-R_2 is considered as a maturation process or molecular aging of the enzyme which involves protein degradation in erythrocytes.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1979-12
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部