Treatment of Hepatocellular Carcinoma by Inter-arterial Infusion with Mitomycin C

Treatment of Hepatocellular Carcinoma by Inter-arterial Infusion with Mitomycin C

Creators Nishioka Mikio

Creators Noda Kenichi

Creators Fukumoto Youhei

Creators Kodama Takahiro

Creators Okita Kiwamu

Creators Shigeta Koujiro

Creators Nishimura Hideo

Creators Harada Tshinori

Creators Takemoto Tadayoshi

The effect of disopyramide on maximum upstroke velocity (V_max) of cardiac action potential was studied with particular reference to its time- and voltage-dependence. The time-dependence (recovery process of V_max during diastolic interval) was assessed by introducing premature stimuli or by interrupting stimuli. The voltage-dependence was examined by changing the external K^+ concentration (〔K^+〕_0). In the presence of the drug, the recovery process of V_max slowed at high 〔K^+〕_0 in early stages and at low 〔K^+〕_0 in late stages during the diastolic interval. Relevance of the present findings to clinical utility of disopyramide as an antiarrhythmic agent was discussed.

[ISSN]0513-1812

[NCID]AA00594272