The effects of ciclosporin and mizoribine on cellular infiltration in rat renal allografts

The effects of ciclosporin (CsA) and mizoribine (MZ) on cellular infiltration in rat allografts were discussed. Transplanted rats were diveided into three groups : CsA treated group, MZ treated group and non-treated group (Cont group). CsA in a dose of 10mg/kg/day or MZ in a dose of 5 mg/kg/day was administred orally for 5 days after transplantation in each treatment group. The mean survival day of each group was 23.7±7.8 days in CsA group, 18.5±2.8 days in MZ group and 8±0.8 days in Cont group respecitively. They were sacrificed every few days, and then renal allografts were used for pathological examinations, those were H E stain and immunoperoxidase stain (ABC method), in which menoclonal antibodies