山口医学

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山口医学 Volume 33 Issue 6
published_at 1984-12

Changes of Glutathione S-transferase during Initiation and Promotion of Hepatocarcinogenesis in Rats

ラット肝発癌過程におけるgluathione S-transferaseの動態 : initiationとpromotionの過程において
Ogino Masaaki
Descriptions
The activities of glutathione S-transferase (GST) in rat liver cytosol were investigated sequentially during initiation and promotion of hepatocarcinogenesis by means of the experimental model of Solt and Farber. The results suggested that both diethylnitrosamine and 2 -fluorenylacetamide induced the activity of GST. It was also found that the induced enzymic levels of GST were suppressed by partial hepatectomy and was considered that the suppression of GST was a reasonable phenomenon to hepatocarcinogenesis.