Effects of Organic Solvents on Superoxide Dismutase Activities in Erythrcoytes and Organs of Dog

Changes in superoxide desmutase (SOD) activities in erythroeytes and organs of dogs were investigated after administration of six kinds of organic solvents, 1,1,1-trichloroethane, 1,1,2-trichloroethane, triehloroethylene, tetrachloroethylene, toluene, and m-xylene. The reaults obtained were as follows. 1. The SOD activities in erythrocytes were not changed after administration of any solvents. 2. The levels of SOD activities in the organs were decreased by the each of chlorinated organic solvents and the degree of effects were varied by the kind of solvents or organs. 3. Toluene and m-xylene did not decreased the SOD activities in organs.