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本稿は、スケートボードのハウトゥ動画の分析を通して、身体技法の教示と修得がどのようになされるのか分析し考察することを目的とするものである。 結果、第1に、手本の提示は教える側の権威の確認のためにもなされていること、第2に、修得に必要となる曖昧な概念を教示する際に、教える側と教わる側の概念のすり合わせがなされていること、第3に、技法の修得が近づいてきた場面では、教わる側から修得のための新概念が提示されそれが教える側によって承認されること、の3点が析出された。 身体技法が教示され修得されようとする際には、上記のような方策が用いられながら、修得という目標に向けて実践が積み重ねられていくことが、本稿からは見えてきた。当然のように行われている身体技法の教示と修得は、実は複雑なやり取りからなされており、そうした複雑さを埋め合わせるための方策が用いられながら成立していることが示唆された。

The hippocampal dentate gyrus has been identified to play a critical role in maintaining contextual memory in many mammalian species. To evaluate learninginduced synaptic plasticity of granule cells, we subjected male rats to an inhibitory avoidance (IA) task and prepared acute hippocampal slices. In the presence of 0.5 μM tetrodotoxin, we recorded miniature excitatory post synaptic currents (mEPSCs) and inhibitory post synaptic currents (mIPSCs) in male rats experiencing four groups: untrained, IA-trained, unpaired, and walk-through. Compared with the untrained, IA-trained, unpaired, and walk-through groups, the unpaired group significantly enhanced mean mEPSC amplitudes, suggesting the experience-induced plasticity at AMPA receptor-mediated excitatory synapses. For inhibitory synapses, both unpaired and walk-through groups significantly decreased mean mIPSC amplitudes, showing the experience-induced reduction of postsynaptic GABAA receptor-mediated currents. Unlike the plasticity at CA1 synapses, it was difficult to explain the learning- specific plasticity at the synapses. However, overall multivariate analysis using four variables of mE(I)PSC responses revealed experience-specific changes in the diversity, suggesting that the diversity of excitatory/inhibitory synapses onto granule cells differs among the past experience of animals include the learning. In comparison with CA1 pyramidal neurons, granule cells consistently showed greater amplitude and frequency of mE(I)PSCs. Fluctuation analysis further revealed that granule cells provide more postsynaptic AMPA receptor channels and greater single-channel current of GABAA receptors of than CA1 pyramidal neurons. These findings show functional differences between two types of principal cells in the hippocampus.

Incontinentia pigmenti (IP; OMIM# 308300) is a rare inherited disease caused by a mutation of IKBKG, which is also known as NEMO, located on Xq28. IP patients usually present with abnormalities of skin, eyes, nails and central nervous system. The neurological damege, which occur usually from neonatal through the early infantile period, leads to neulogical complication such as development retardation, motor paralysis and epilepsy. However, there has been little study done concerning the effect of therapy for the neural abnormalities. We have investigated the clinical findings in a female IP case with a novel mutation of IKBKG for six years due to disclosing the neurological prognosis and the immunological features. It is hoped that the present study will contribute to a better management of IP patients.

Androgen receptor (AR)-signaling plays an important role in promoting tumor cell survival and the development of castration-resistant prostate cancer (CRPC). Androgen deprivation therapy is the basic therapeutic strategy for AR signaling blockade, but that effects wonʼt last long and most of metastatic prostate cancer show castration resistance. Recently, new agents, AR Axis Targeted agents (ARAT), have been developed. We have been developing our bench-to-bedside translational research to elucidate the mechanisms of drug resistance in prostate cancer. This review describes our investigational results and recent advances in CRPC with ARAT treatment strategy.

The quadratic unconstrained binary optimization (QUBO) problem is categorized as an NP-hard combinatorial optimization problem. The variable neighborhood search (VNS) algorithm is one of the leading algorithms used to solve QUBO problems. As neighborhood structure change is the central concept in the VNS algorithm, the design of the neighborhood structure is crucial. This paper presents a modified VNS algorithm called "B-VNS", which can be used to solve QUBO problems. A binomial trial was used to construct the neighborhood structure, and this was used with the aim of reducing computation time. The B-VNS and VNS algorithms were tested on standard QUBO problems from Glover and Beasley, on standard max-cut problems from Helmberg-Rendl, and on those proposed by Burer, Monteiro, and Zhang. Finally, Mann-Whitney tests were conducted using α = 0.05, to statistically compare the performance of the two algorithms. It was shown that the B-VNS and VNS algorithms are able to provide good solutions, but the B-VNS algorithm runs substantially faster. Furthermore, the B-VNS algorithm performed the best in all of the max-cut problems, regardless of problem size, and it performed the best in QUBO problems, with sizes less than 500. The results suggest that the use of binomial distribution, to construct the neighborhood structure, has the potential for further development.

Zero-determinant strategies are a class of memory-one strategies in repeated games which unilaterally enforce linear relationships between payoffs. It has long been unclear for what stage games zero-determinant strategies exist. We provide a necessary and sufficient condition for the existence of zero-determinant strategies. This condition can be interpreted as the existence of two different actions which unilaterally adjust the total value of a linear combination of payoffs. A relation between the class of stage games where zero-determinant strategies exist and other class of stage games is also provided.

The purpose of this paper is to present a macroeconomic model, in which the bank determine the loan interest rate and the deposit interest rate by assuming the loan demand curve and the deposit supply curve. The bank adjusts the loan interest rate and the deposit interest rate while observing the difference between the assumed demand for loan and the actual demand for loan.

Taiwan has not yet been singed the “Convention on Nuclear Safety; CNS” that was adopted by the International Atomic Energy Agency （IAEA） in 1994. However, if these international activities help promote nuclear safety, Taiwan must participate in it and fulfill its related obligations. Therefore, despite Taiwan being a non-member state to the CNS, it is required by the Convention to act as a member state to meet all the requirements addressed in the CNS. Ensuring the public trust of nuclear safety regulations in the most important policy issue for the location, operation, waste disposal and off-commissioning of nuclear power plants, etc. As part of an international comparison of nuclear safety regulatory bodies in the East Asian region, this note organizes and evaluates the independence and transparency of Taiwan’s regulatory bodies.