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Journal of the Physical Society of Japan Volume 91 Issue 8 pp. 084801 -
published_at 2022-07-11
Zero-determinant strategies are a class of memory-one strategies in repeated games which unilaterally enforce linear relationships between payoffs. It has long been unclear for what stage games zero-determinant strategies exist. We provide a necessary and sufficient condition for the existence of zero-determinant strategies. This condition can be interpreted as the existence of two different actions which unilaterally adjust the total value of a linear combination of payoffs. A relation between the class of stage games where zero-determinant strategies exist and other class of stage games is also provided.
Creators : Ueda Masahiko Publishers : Physical Society of Japan Updated At : 2022-07-19 16:50:23
Algorithms Volume 15 Issue 6 pp. 192 -
published_at 2022-06-02
The quadratic unconstrained binary optimization (QUBO) problem is categorized as an NP-hard combinatorial optimization problem. The variable neighborhood search (VNS) algorithm is one of the leading algorithms used to solve QUBO problems. As neighborhood structure change is the central concept in the VNS algorithm, the design of the neighborhood structure is crucial. This paper presents a modified VNS algorithm called "B-VNS", which can be used to solve QUBO problems. A binomial trial was used to construct the neighborhood structure, and this was used with the aim of reducing computation time. The B-VNS and VNS algorithms were tested on standard QUBO problems from Glover and Beasley, on standard max-cut problems from Helmberg-Rendl, and on those proposed by Burer, Monteiro, and Zhang. Finally, Mann-Whitney tests were conducted using α = 0.05, to statistically compare the performance of the two algorithms. It was shown that the B-VNS and VNS algorithms are able to provide good solutions, but the B-VNS algorithm runs substantially faster. Furthermore, the B-VNS algorithm performed the best in all of the max-cut problems, regardless of problem size, and it performed the best in QUBO problems, with sizes less than 500. The results suggest that the use of binomial distribution, to construct the neighborhood structure, has the potential for further development.
Creators : Pambudi Dhidhi | Kawamura Masaki Publishers : Multidisciplinary Digital Publishing Institute Updated At : 2022-06-13 10:46:59
The bulletin of the Yamaguchi Medical School Volume 69 Issue 1-2 pp. 21 - 25
published_at 2022-06
Incontinentia pigmenti (IP; OMIM# 308300) is a rare inherited disease caused by a mutation of IKBKG, which is also known as NEMO, located on Xq28. IP patients usually present with abnormalities of skin, eyes, nails and central nervous system. The neurological damege, which occur usually from neonatal through the early infantile period, leads to neulogical complication such as development retardation, motor paralysis and epilepsy. However, there has been little study done concerning the effect of therapy for the neural abnormalities. We have investigated the clinical findings in a female IP case with a novel mutation of IKBKG for six years due to disclosing the neurological prognosis and the immunological features. It is hoped that the present study will contribute to a better management of IP patients.
Creators : Sakata Yasufumi | Hirano Reiji | Yasudo Hiroki | Shimomura Yutaka | Takada Hidetoshi | Suehiro Yutaka | Ohga Shouichi | Hasegawa Shunji Publishers : Yamaguchi University School of Medicine Updated At : 2022-06-08 10:48:58
The bulletin of the Yamaguchi Medical School Volume 69 Issue 1-2 pp. 11 - 19
published_at 2022-06
The hippocampal dentate gyrus has been identified to play a critical role in maintaining contextual memory in many mammalian species. To evaluate learninginduced synaptic plasticity of granule cells, we subjected male rats to an inhibitory avoidance (IA) task and prepared acute hippocampal slices. In the presence of 0.5 μM tetrodotoxin, we recorded miniature excitatory post synaptic currents (mEPSCs) and inhibitory post synaptic currents (mIPSCs) in male rats experiencing four groups: untrained, IA-trained, unpaired, and walk-through. Compared with the untrained, IA-trained, unpaired, and walk-through groups, the unpaired group significantly enhanced mean mEPSC amplitudes, suggesting the experience-induced plasticity at AMPA receptor-mediated excitatory synapses. For inhibitory synapses, both unpaired and walk-through groups significantly decreased mean mIPSC amplitudes, showing the experience-induced reduction of postsynaptic GABAA receptor-mediated currents. Unlike the plasticity at CA1 synapses, it was difficult to explain the learning- specific plasticity at the synapses. However, overall multivariate analysis using four variables of mE(I)PSC responses revealed experience-specific changes in the diversity, suggesting that the diversity of excitatory/inhibitory synapses onto granule cells differs among the past experience of animals include the learning. In comparison with CA1 pyramidal neurons, granule cells consistently showed greater amplitude and frequency of mE(I)PSCs. Fluctuation analysis further revealed that granule cells provide more postsynaptic AMPA receptor channels and greater single-channel current of GABAA receptors of than CA1 pyramidal neurons. These findings show functional differences between two types of principal cells in the hippocampus.
Creators : Han Thiri Zin | Sakimoto Yuya | Mitsushima Dai Publishers : Yamaguchi University School of Medicine Updated At : 2022-06-08 10:41:18
The bulletin of the Yamaguchi Medical School Volume 69 Issue 1-2 pp. 1 - 9
published_at 2022-06
Androgen receptor (AR)-signaling plays an important role in promoting tumor cell survival and the development of castration-resistant prostate cancer (CRPC). Androgen deprivation therapy is the basic therapeutic strategy for AR signaling blockade, but that effects wonʼt last long and most of metastatic prostate cancer show castration resistance. Recently, new agents, AR Axis Targeted agents (ARAT), have been developed. We have been developing our bench-to-bedside translational research to elucidate the mechanisms of drug resistance in prostate cancer. This review describes our investigational results and recent advances in CRPC with ARAT treatment strategy.
Creators : Matsumoto Hiroaki | Matsuyama Hideyasu Publishers : Yamaguchi University School of Medicine Updated At : 2022-06-08 10:37:44
Journal of the physical society of Japan Volume 91 pp. 054804 -
published_at 2022-04-21
Creators : Ueda Masahiko Publishers : Physical Society of Japan Updated At : 2022-04-28 14:22:16
published_at 2022-04
背景:経食道心エコー図検査(TEE)は、心房細動(AF)に対する肺静脈隔離術(PVI)前の左心房(LA)および左心耳(LAA)における血栓の有無の評価を行うゴールドスタンダードな検査である。TEEは比較的安全とされているが、近年PVIに先行するTEEが食道粘膜損傷(EMI)を引き起こす可能性があることが報告された。 目的:PVIを施行したAF患者におけるTEE関連EMIの発生率とその危険因子を検討すること。 方法と結果:3D TEEプローブを用いた術前TEEと術後上部消化管内視鏡検査を受けたPVI患者262人を対象とした。TEE関連EMIは16人(6.1%)の患者(18病変)、PVI関連EMIは5人(1.9%)の患者(8病変)で認められた。TEE関連EMIは上部食道の右側と中部食道の左前側で多く認められた。1人の患者で軽度の胸部違和感を認めた。多変量解析では、高齢はTEE関連EMIの独立した危険因子であった(オッズ比1.08、95%信頼区間1.01-1.16;P=0.0274)。 結語:3D TEEプローブによるTEE関連EMIは、PVI施行患者の6.1%で認められ、高齢であることはTEE関連EMIの危険因子であった。これらの所見から、特に高齢患者においては、LA・LAAにおける血栓評価として他の画像診断を考慮する必要があるかもしれない。
Creators : 小室 あゆみ Updated At : 2022-07-07 15:32:56
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 3 - 8
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 14:05:30
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 156 - 159
published_at 2022-03-31
Creators : 渡邉 正巳 Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:43:18
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 11 - 14
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 14:33:41
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 128 - 130
published_at 2022-03-31
Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:31:56
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 15 - 16
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 14:37:05
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 21 - 109
published_at 2022-03-31
Creators : Yokoyama Shigeki | Tabata Naohiko | Mizukubo Syoko Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:09:52
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 127 - 127
published_at 2022-03-31
Creators : Tabata Naohiko Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:28:22
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 124 - 126
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:24:19
館蔵資料調査研究報告書 Volume 7
published_at 2022-03-31
Creators : 山口大学埋蔵文化財資料館 Publishers : 山口大学埋蔵文化財資料館 Updated At : 2022-03-24 13:37:29
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 17 - 20
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 14:46:52
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 1 - 2
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 11:26:33
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 9 - 10
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 14:21:04
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 123 - 123
published_at 2022-03-31
Creators : Yokoyama Shigeki Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:19:12
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 110 - 122
published_at 2022-03-31
Creators : Yokoyama Shigeki | Mizukubo Syoko Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:14:18
Yamaguchi University Archaeological Museum report Volume 15-16 pp. 131 - 155
published_at 2022-03-31
Publishers : Yamaguchi University Archaeological Museum Updated At : 2022-04-18 15:34:33
The philosophical studies of Yamaguchi University Volume 29 pp. 37 - 49
published_at 2022-03-28
Creators : Fujikawa Satoshi Publishers : 山口大学哲学研究会 Updated At : 2022-04-18 11:11:40
The philosophical studies of Yamaguchi University Volume 29 pp. 17 - 36
published_at 2022-03-28
In recent years, discussions about anti-natalism have been activated in various areas. This movement has been started with David Benatar’s controversial book, Better Never to Have Been: The Harms of Coming into Existence, published in 2006. The purpose of this article is to examine what the type of questions has been raised in the movement, especially into pedagogy. Firstly, we survey historical genealogy of anti-natalism, as well as Benatar’s discussion. History of anti-natalism has been long both in the East and the West, and Benatar adds new insights to the genealogy using the method of analytic philosophy. Secondly, we clarify social conditions under which anti-natalism has been widely accepted today. Particularly we focus on contemporary topic such as reproductive ethics, various gaps in society, environmental problems. Then, we suggest there are three issues within recent anti-natalism, and consider the questions brought by each issue.
Creators : Tanaka Tomoki | Muramatsu Tomo | Higuchi Hiromu Publishers : 山口大学哲学研究会 Updated At : 2022-04-18 11:08:23
The philosophical studies of Yamaguchi University Volume 29 pp. 1 - 15
published_at 2022-03-28
In another paper I pointed out that Henri Bergson (1859-1941), a French philosopher, in his early years argues on <sensibility> from a similar viewpoint to his contemporaries’. In this paper I aim to examine his notion of <sensibility> in his later years, focusing on The Two Sources of Morality and Religion (1932). Although rarely pointed out, in The Two Sources Bergson argues on <sensibility> from his particular point of view. He proposes “a psychology which accords so extensive and so handsome a place to sensibility,” where emotion gains an advantage over intellect and volition. When we compare The Two Sources with Technical and Critical Vocabulary of the Philosophy, a French encyclopedia published in 1926, we see that Bergson has his conception in common with his contemporaries to some extent, but that on the other hand he is outstanding among his contemporaries especially for his paying attention to the <superior component> of <sensibility>, which is characterized by activity and unity, in contrast to the <inferior component>, which is characterized by passivity and multiplicity.
Creators : Murakami Ryu Publishers : 山口大学哲学研究会 Updated At : 2022-04-18 10:57:04