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Viral Infections and Chromosome Aberrations

The bulletin of the Yamaguchi Medical School Volume 17 Issue 1-2 Page 85-126
published_at 1970-06
A020017000107.pdf
[fulltext] 8.89 MB
Title
Viral Infections and Chromosome Aberrations
Creators Shuto Tsugihiko
Source Identifiers
Chromosome studies were carried out in cultured peripheral blood leukocytes from 197 cases of various viral infections of man in cultured peripheral blood leukocytes from African green monkeys infected with rubella virus (in vivo), and in cultured BHK, RE, GMK cells infected with rubella virus, in cultured BHK, HEK cells infected with adenovirus type 4, 12 and 18 (in vitro). As the results, 73 of 197 cases of viral infections rubella, mumps, varicella, measles, viral meningo-encephalitis, viral pneumonia, infectious mononucleosis and herpes zoster patients, showed relatively higher incidence of chromosome breakages (0-33%) than the controls (0-7%). On 5 cases of African green monkeys infected with rubella virus, abnormal retaphase plates were an average 10.7, 15.4, 9.5, 9.9, 8.0% as compared with 6.6, 7.0, -, 0, 4.0% of the controls. The difference was significant. On BHK, RE and GMK cells infected with rubella virus, abnormal metaphase plates were at 7.0-25.2, 0-14.6 and 7.0-14.6% as compared with 4.0-8.0, 6.9-8.3 and 2.0-9.0% of the controls, being slightly or moderately different. And on BHK cells infected with adenovirus type 4, 12 and 18, abnormal metaphase plates were 0-20, 7-17 and 0-37% as compared with 0-6% of the controls, being greatly different. On HEK cells, abnormal metaphase plates were 8-15, 0-40 and 7-14% as compared with 3-7% of the controls, being greatly different. These abnormal chromosomes in present studies were mostly chromatid or isochromatid breaks and fragments with a few to moderate incidence of extensively impaired chromosomes
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1970-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部