Contents Menu

Synthesis and reactions of 3- and 8-ethynyl-1-azaazulenes

Heterocycles Volume 58 Page 283-292
published_at 2002
2007020165.pdf
[fulltext] 3.17 MB
Title
Synthesis and reactions of 3- and 8-ethynyl-1-azaazulenes
Creators Fujii Hiroyuki
Creators Abe Noritaka
Creators Umeda Noritaka
Creators Kakehi Akikazu
3-iodo-1-azaazulenes were easily ethynylated by Sonogashira-Hagihara reaction to give 3-ethynyl-1-azaazulenes. Cyclization of 2-amino-3-ethynyl-1-azaazulene was achieved by heating in the presence of copper(II) acetate or copper(II) trifluoromethanesulfonate, and 1,9-diaza-1H-cyclopent[a]azulene derivatives were obrained. Reaction of 2-chloro-1-azaazulene with lithium phenylacetylide gave 3-chloro-1-(2-chloro-1-azaazulen-8-yl)-2-phenyl-2a-aza-2H-cyclopent[cd]azulene together with 2-chloro-8-phenylethynyl-1-azaazulene.
Languages eng
Resource Type journal article
Publishers 日本複素環化学研究所
Date Issued 2002
File Version Version of Record
Access Rights open access
Relations
[ISSN]0385-5414
[NCID]AA00663739
Schools 総合科学実験センター 大学院医学系研究科(理学)