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Effects of basic fibroblast growth factor (bFGF) on the bone grafting

山口医学 Volume 53 Issue 1 Page 55-65
published_at 2004-02-29
B030053000107.pdf
[fulltext] 4.75 MB
Title
Basic fibroblast growth factor(bFGF)による遊離骨移植に対する効果
Effects of basic fibroblast growth factor (bFGF) on the bone grafting
Creators Murata Yoichiro
Source Identifiers
Creator Keywords
Basic Fibroblast Growth Factor(bFGF) 腸骨移植 コラーゲン
Bone is the most frequently transplanted tissue in humans. Bone grafting is a common procedure to fill bone defects, such as when a fracture dose not heal properly, or to replace bone lost to tumor surgery or trauma. The grafted bone is resorbed and replaced by new tissue moving from host bone, however, the incorporation through slow remodeling may initially weakens the graft, The purpose of this stydy was to investivate the effect of basic fibroblast growth factor (bFGF) on the incorporation of a bone graft. bFGF (0, 10, 100, 500, or, 1,000ng) was mixed with a collagen gel and implanted into bone grafts taken from rabbit iliums. The bone grafts were put back in the iliums as they were and harvested at 1,2,and 4 weeks after surgery. X-ray radiographs of the bone grafts were taken using SOFTEX. Histological examination and histomorphometric analysis were performed on bone samples. Treatment with bFGF had greatly stimulated osteogenesis in the bone grafts both radiologically and histologically in comrarison with untreated grafts (those filled with plain collagen gel). Of a total of 4 dose-groups, the 100ng group exhibited the best result, but the osteogenesis was poorer in the higherdose groups. These effects were dvident as long as 4 weeks postoperatively. These findings suggest that bFGF may be practical and important candidate for use in bone grafting procedures.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2004-02-29
Rights
本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002773899/
Schools 医学部