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Expressions of matrix gla protein (MGP) in the spinal ligaments : effects of age and calcification/ossification

山口医学 Volume 53 Issue 1 Page 29-38
published_at 2004-02-29
B030053000104.pdf
[fulltext] 4.24 MB
Title
脊柱靭帯におけるMGP(Matrix Gla Protein)の発現 : 年齢及び石灰化・骨化との関連について
Expressions of matrix gla protein (MGP) in the spinal ligaments : effects of age and calcification/ossification
Creators Miyazaki Noriyuki
Source Identifiers
Creator Keywords
Matrix Gla Protein 脊柱靭帯 骨化
Matrix γ-carboxyglutamic acid (Gla) Protein (MGP), a mineral binding vitamin K-dependant protein exists in the matrix of cartilage and in the media of the aortic wall and is considered as a regulator of physiological or pathological clcification. Calcification of the spinal ligaments have received attention in a number of reprots, as in some cases the spinal cord is compressed and myelopathy occurs. In the present study, to investigate the role of MGP in the calcification or the ossification of the spinal ligaments, we examined expression of MGP in the lumber spinal yellow ligaments of human. In immunohistochemical study we found the diffuse staining of MGP in the matrix of yellow ligaments and MGP was accumulated at the enthesis of the ligament and the circumference of the site of pathological calcification.There was a tendency in staining of MGP that they were better stained in young patients than old ones. Semiquantitative RT-PCP to amplify MGPm-RNA was performed to measure the quantity of MGP mRNA in the yellow ligaments, showing that the quantity of MGP mRNA was decreased in proportion to aging. These results suggest that expression of MGP in spinal ligament could be a potential clue for elucidating how heterotoropic calcification or ossification develops in ligament tissue.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2004-02-29
Rights
本文データは山口大学医学会の許諾に基づきCiNiiから複製したものである()
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
[isVersionOf] [NAID]http://ci.nii.ac.jp/naid/110002773896/