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Molecular Epidemiology of Nosocomial Infection

山口医学 Volume 42 Issue 3 Page 185-191
published_at 1993-06
Title
分子疫学的手法による院内感染の解明
Molecular Epidemiology of Nosocomial Infection
Creators Nakazawa Teruko
Source Identifiers
Creator Keywords
院内感染 Pseudomonas cepacia 分子疫学 DNA fingerprinting ribotyping
To prevent nosocomial outbreaks, elucidation of the source of infection and the mode of transmission is the primary importance. Molecular epidemiology by using DNA fingerprinting and ribotyping is a powerful tool for such analysis, since typing by these methods is based on the whole genome structure. A nosocomial outbreak of Pseudomonas cepacia infection in immunocompromized patients was analyzed by DNA fingerprinting as well as by conventional methods and revealed that the outbreak was associated with contaminated nebulizers. DNA fingerprinting and ribotyping were evaluated with clinical isolates of Pseudomonas cepacia from various sources. Both the methods gave almost identical results, indicating the usefulness of these techniques. Typing by the plasmid profile was reliable only in limited cases. Conventional typing methods such as enzyme typing, bacteriocin typing, phage typing, and serotyping should be used with caution in nosocomial infection, because these are based on phenotypes that are changeable by few genetic events.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1993-06
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部