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Spontaneous Amyloidosis in Senile ICR Mice Maintained Semi-barrier System

山口医学 Volume 41 Issue 6 Page 439-449
published_at 1992-12
Title
セミバリアシステムで飼育した高齢ICRマウスの自然発症アミロイドーシスについて
Spontaneous Amyloidosis in Senile ICR Mice Maintained Semi-barrier System
Creators Ikegami Jiro
Source Identifiers
Creator Keywords
アドロイドーシス マウス セミバリアシステム AApoA II g 蛋白
Incidence and characterization of amyloid deposits were refered in 64 mice, aged 83 weeks old of each sex (26 male and 38 female) of inbred Sic: ICR. The mice were raised under semi-barrier conditions, room temperature at 22~26℃, ventilation at 20 times/hour and relative humidity at 45~65% with 12 hour light-dark cycle. They were fed a commercial diet (FR-2 10 kGy, Funabashi Farms, Chiba) and filtrated tap water ad libitum. Histologically amyloidosis were observed in 35 out of 64 mice(54.7%), 16 out of 26 male mice(61.5%) and 19 out of 38 female mice(50%). The amyloid deposits were detected in 32 out of64 mice(50%) in the kidney, 30 out of 64(46.9%) in the small intestine, 26 out of 64(40.6%) in the liver, 25 out of 64(39.1%) in the adrenal gland, 24 out of 62(38.7%) in the mesenteric lymph node, 20 out of64(31.2%)in the lung and 14 out of64(21.9%) in the spleen. Immunohistochemically 34 mice had AApoA II g amyloid protein. Only one mouse had AA amyloid protein.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1992-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部