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Effects of Butoctamide Hydrogen Succinate and Nitrazepam on Sleep

山口医学 Volume 41 Issue 6 Page 377-385
published_at 1992-12
Title
セミコハク酸ブドクタミドとニトラゼパムの睡眠に及ぼす影響 : 比較試験による検討
Effects of Butoctamide Hydrogen Succinate and Nitrazepam on Sleep
Creators Sekimoto Masanori
Source Identifiers
Creator Keywords
セミコハク酸ブトクタミド REM 睡眠 ニトラゼバム
In the present study, the effects of butoctamide hydrogen succinate (BAHS) and nitrazepam on sleep were studied in 12 healthy male subjects. The subjects were divided into three groups consisting of 4 subjects who were given BAHS 600mg, nitrazepam 5mg, and BAHS 600mg+nitrazepam 5mg, respectively. Polygraphic recordings were made for 8 consecutive nights from each subject. Placebo was given on the first 3 nights and the last 2 nights, and drug was administered on the fourth, fifth, and sixth nights. Before falling asleep and after arising the next morning, the subjects were requested to fill out subjective assessments for sleep. The polysomnogarams were evaluated by computerized automatic analysis using the interval histogram method. The first night was excluded from the data analysis because of the first night effect. BAHS increased REM sleep and decreased stage 2 significantly
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1992-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部