Contents Menu

Effect of substance P on the lower esophageal sphinvter and pasophysiology of esophageal achalasia

山口医学 Volume 39 Issue 2 Page 141-148
published_at 1990-04
Title
噴門括約機構におけるsubstraction Pの関与と食道アカラシアの病態生理
Effect of substance P on the lower esophageal sphinvter and pasophysiology of esophageal achalasia
Creators Ozasa Hiroaki
Source Identifiers
The effect of substance P on the lower esophageal sphincter (LES) was investigated in normal dogs, dogs with experimentally-induced achalasia, normal controls and patients with achalasia. 1. Substance P caused contraction and vasoactive intestinal polypeptide (VIP) relaxation of the LES. 2. Substance P-induced, but not tetragastrin-induced, contraction of the LES in normal was inhbited by atropine. 3. substance P-induced contraction of the LES was decreased in achalasia. 4. Substance P-inhibited VIP relaxation in achalasia was less than in normal sontrols. 5. Immunohistologically, the number of substance P and VIP neurons was decreased in experimental and clinical achalasia. 6. Radioimmunoassay documented a decrease in substance P and VIP concentrations in the lower esophageal musculer layer in achalasia. This suggests that substance P receptors are present in cholinergic neurons innervating the LES and VIP receptors are present on the sphincter itself. Thus a decrease in the number of substance P neurons and VIP neurons in Auerbach's plexus could cause denervation hypersensitivity of the LES to ciculating acetylcholine, which finally results in the increased LES pressure seen in achalasis.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1990-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部