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Local cerebral glucose utilization and cerebral blood flow following CO-intoxication in rats

山口医学 Volume 39 Issue 1 Page 101-109
published_at 1990-02
Title
急性一酸化炭素中毒後の局所脳代謝・血流変動に関する研究
Local cerebral glucose utilization and cerebral blood flow following CO-intoxication in rats
Creators Miyawaki Hiroshi
Source Identifiers
To clarify the mechanisms of delayed neuronal dysfunction following carbon monoxide (CO)-intoxication, local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) were measured respectively in rats using [^<14>C]-autoradiographic methods. Behavioral changes were also observed for 14 days. CO-intoxication was induced with 0.1% CD for 2 hours under light halothane anesthesia. At the end of CO-inhalation CO hemoglobin was approximately 60%. There was no significant difference in the behavior judged by locomotor activity and emotional behavior for 14 days between the CO-intoxication and the shamoperated group. In the neocorticied, caudate n., pallidus, hippocampus (CAI) and hypothalamus, LCGU were significantly lower by 13 to 27% at 7 days and by 15 to 24% at 14 days than those in the sham-operated group, while they did not change significantly at 3 days. In the substantia nigra compacta, LCGU was transiently elevated by 14% at 7 days. LCBF measured at 14 days was significantly lower by 13 to 18% in the caudate n., pallidus and septal n. than those in the sham-operated group. These results demonstrated the delayed changes in LCGU as a reflection of neuronal dysfunction in the neocorticies, extrapyramidal and limbic systems following CO-intoxication.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1990-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部