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Anesthetic effects on neurological deficits and blood-brain barrier function follwing focal cerebral ischemia in cats

山口医学 Volume 39 Issue 1 Page 91-99
published_at 1990-02
Title
麻酔薬が局所脳虚血後の神経学的障害および血液脳関門におよぼす効果
Anesthetic effects on neurological deficits and blood-brain barrier function follwing focal cerebral ischemia in cats
Creators Nakajima Ken
Source Identifiers
The present study examined the effects of anesthetics upon neurological deficits and blood-brain barrier function following focal cerebral ischemia produced by occlusion of the middle cerebral artery for 3 hours in cats. Both neurological deficit score and Evans blue penetration index examined after reperfusion were less in cats anesthetized with halothane or penetobarbital during the early reperfusion period, compared to cats anesthetized with halothane only during occlusion of the middle cerebral artery. The results were not significantly different whether halothane or pentobarbital was used during the repergusion period. When change in blood pressure after reperfusion and Evants blue penetration index in all cats were pooled, the degree of barrier dysfunction was significantly correlated with the reperfusion increase in blood oressure. Thus, it can be said that stabilization of systemic blood pressure with anesthetics contributes to the improvement of post-ischemic blood-brain barrier function, regardless of anesthetics used, Hence, the avoidance of post-ischemic hypertension may be more important than the choice of anesthetics in such situations.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1990-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部