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Modification of cerebral arterial tone and reactivity by external potassium and magnesium ratio in the dog

山口医学 Volume 39 Issue 1 Page 73-81
published_at 1990-02
Title
摘出脳血管におけるカリウム、マグネシウムイオン比の血管緊張及び収縮反応に及ぼす影響
Modification of cerebral arterial tone and reactivity by external potassium and magnesium ratio in the dog
Creators Murakawa Toshisuke
Source Identifiers
The interaction of external potassium ([K^+]_0) and magnesium ([Mg^<2+>]_0) ions on the vasoconstrictions induced by these cations was investigated in isolated canine middle cerebral and basilar artetial smooth muscle. In addition, the effects of the [K^+]_0/[Mg^<2+>]_0 ratio on the reactivity and contractility to serotonin in these cerebral vascular tissues were examined. The results were similar, irrespective of whether helically-cut strips or rings were utilized. [K^+]_0 was altered over 0-7.1mM/L and [Mg^<2+>]_0 between 0-4.8mM/L. The results indicate relationship between the concentration of [K^+]_0 and degree of vasoconstriction produced upon withdrawal of [Mg^<2+>]_0 was observed over the range of 1-6mM/L [K^+]_0. As [K^+]_0 was increased, stepwise, the slow (s-) phase of the contraction became attenuated, while the magnitude of the fast (F-) phase became progressively smaller. Contractions produced by withdrawal of [K^+]_0 were modified by [Mg^<2+>]_0 : the higher the [Mg^<2+>]_0, the less tension upon withdrawal of [K^+]_0. Contractility to serotonin was depressed when [K^+]_0 waslowered
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1990-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部