Contents Menu

Role of active oxygen species in hemorrhagic shock induced small intestinal mucosal lesions in the rat

山口医学 Volume 38 Issue 1 Page 69-75
published_at 1989-02
Title
脱血性ショックおよび再疎通時のラット小腸粘膜における活性酸素の影響
Role of active oxygen species in hemorrhagic shock induced small intestinal mucosal lesions in the rat
Creators Yoshimura Shunji
Source Identifiers
The role of active oxygen species in the pathogenesis of intestinal mucosal damage was investigated in a rat model produced by hemorrhagic shock. After the treatment of ischemia-reperfusion, intestinal mucosal damage was observed in jejunum and ileum. Intestinal mucosal blood flow and superoxide dismutase (SOD) activity decrease in jejunum and ileum. Treatment of allopurinol, SOD and antibiotics inhibited intestinal mucosal demage after reperfusion. After reperfusion of fresh blood withdrawn by other rat, in exchange for shedblood, intestinal mucosal lesions were reduced. These results suggest that active oxygen species may be involved in the pathogenesis of hemorrhagic shock induced small intestinal mucosal damage in association with intestinal mucosal blood flow, endtoxin of intestinal bacteriaand other factors in withdrawn blood.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1989-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部