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Supplementary study on effects of actue 1,1,1-trichloroethane inhalation on ventricular contractility in dogs

山口医学 Volume 37 Issue 3 Page 175-180
published_at 1988-06
Title
1,1,1-trichloroethaneの吸入による心収縮能の変化に関する実験的研究補遺
Supplementary study on effects of actue 1,1,1-trichloroethane inhalation on ventricular contractility in dogs
Creators Tanaka Haruko
Source Identifiers
Anesthetized dogs were exposed to 1,1,1-trichloroethane (1,1,1-TCE) and left ventricular peak dP/dt, left ventricular pressure (LVP), dP/dt/P40 and Vmax were determined to investigate the actue effects of the solvent on bentricular contractility. Decrease in peal dP/dt, LVP, dP/dt/P40 and Vmax were observed following exposure to 1,1,1-TCE. The threshold concentration to produce the decrease was approximately 0.2%, and a dose-reponse relationship was observed between the 1,1,1-TCE concentration and the degree of decrease in every contractile parameter. Furthermore, highly significant correlations were seen between the degree of decrease in 4 parameters following 1,1,1-TCE inhalation. Based on the results mentioned above, it was confirmed that left ventricular contractility in the period of isovolumetric contraction decrease following actue 1,1,1-TCE inhalation.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1988-06
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部