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Relationoships between hetatic encephalopathy and GABA in acute liver failure

山口医学 Volume 37 Issue 1 Page 13-20
published_at 1988-02
Title
急性肝不全における肝性脳症とγ-aminobutyric acidの関連性についての考察
Relationoships between hetatic encephalopathy and GABA in acute liver failure
Creators Yasunaga Mitsuru
Source Identifiers
This investigation was aimed to clarify the relationships between hepatic encephalopathy and GABA, clinically and experimentally. In the patients with acute liver failure, the serum levels of GABA-like activity were not ralized significantly as compared with the controls. However, marked increase of GABA-like activity was observed in the patients showing coma grade V, in whom gastrointestinal bleeding was complicated. The serum levels of GABA-like activity did not show any correlation with the serum ammonia and ammino acid imbalance. In the animal study using rats carrying actue liver failure, the serum levels of GABA-like activity never changed, in spite of the increase of aromatic ammino acid. While GABA-like activity in the hippocampus were ralized and the specific binding sites of ^3H-muscimol decreased in the early stage of acute liver failure, but these levels recovered in spite of the porgression of liver failure. In conclusion, our data did not always support the hypothesis that GABA might play an important role for the induction of hepatic encephalopathy.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1988-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部