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The Effect of Zinc on Brain Enzymes with Special Reference to Enzymohistochemical Changes in Ammon’s Horn

The bulletin of the Yamaguchi Medical School Volume 15 Issue 1 Page 59-69
published_at 1968-03
A020015000105.pdf
[fulltext] 1.95 MB
Title
The Effect of Zinc on Brain Enzymes with Special Reference to Enzymohistochemical Changes in Ammon’s Horn
Creators Watanabe Masanori
Source Identifiers
Changes in brain enzymes produced by zinc were histochemically studied to elucidate the effect of zinc on function of the central nervous system. Since systemically or intracerebral1y injected 65Zn showed a characteristic distribution in Ammon's horn, attention was focused on histochemical changes in this region. The observations may be summarized as follows : 1) The activities of cytochrome oxidase, succinic dehydrogenase, DPN-and TPN-diaphorase were inhibited by systemic or intracerebral injection of zinc. Particulary the activities of DPN-and TPN-diaphorase were strongly inhibited. These findings indicate that zinc inhibits the oxidative process in the brain. 2) Intracerebral injection of zinc diminished cholinesterase activity in the layer of mossy fibers in 4-5 days, when the injected 65Zn showed distinct localization in this layer. 3) The activities of monoamine oxidase and acid phosphatase remained unchanged. 4) A little larger dose of zinc produced tonic extensor seizures with running or hopping movements in 4-5 days after intracerebra1 injection. Relationship between the behavioral changes and the histochemical changes in brain enzymes produced by zinc is discussed briefly.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1968-03
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部