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Assessment of Hemodynamic Determinants of Exercise Capacity : An Importance of Left Ventricular Early Diastolic Performance

山口医学 Volume 41 Issue 6 Page 419-428
published_at 1992-12
Title
運動耐容能規定因子としての左室拡張期特性
Assessment of Hemodynamic Determinants of Exercise Capacity : An Importance of Left Ventricular Early Diastolic Performance
Creators Yamamoto Takeshi
Source Identifiers
Creator Keywords
運動耐容能 嫌気性代謝閾値 左室拡張期特性
To assess the effect of resting left ventricular (LV) diastolic function on exercise capacity, 18 patients with old myocardial infarction (mean age 61±9 yrs) underwent cardio-pulmonary stress test for measuring anaerobic threshold (AT) and left ventriculography (LVG) with simultaneous measurement of left ventricular pressure (LVP). From frame-by-frame analysis of LVG and LVP, we calculated time constant of LV pressure decay (T), normalized peak filling rate (nPFR), normalized end-diastolic compliance (dV/VdP)ed, and stiffness constant (k). T was prolonged (50±9 msec), nPFR was decreased (1.41±0.4386^<-1>) and (dV/VdP)ed was increased (0.017±0.012mmHg^<-1>). But k (0.039±0.030) showed no significant difference compared with our previously reported normal values. Although there were no significant correlations between AT and (dV/VdP)ed or k, AT had a significant negative correlation with T(r=-0.63, p<0.05), and a positive correlation with nPFR (r=0.70, p<0.05). Thus, this study suggests that the early left ventricular diastolic property but not LV compliance might play an important role for determining exercise capacity in patients with old myocardial infarction.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1992-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部