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The role of vascular endothelium in carbon dioxide-induced vascular relaxation

山口医学 Volume 37 Issue 1 Page 81-87
published_at 1988-02
Title
炭酸ガスの血管平滑筋弛緩作用に及ぼす内皮細胞の役割
The role of vascular endothelium in carbon dioxide-induced vascular relaxation
Creators Matsumoto Mishiya
Source Identifiers
The effects of hypercapnia(Pco_2 91±2mmHg) on the contraction induced by norepinephrine in isolated rat aorta were studied. Isolated vascular rings obtained from rat aorta were mounted in the 20ml muscle shamber under the isometric sondition. The contractile concentration-effect curve for norepinephrine was altered to the right and maximal developed tension was significantly attenuated 28% by hypercapnia in rings with endothelium. By removal of endothelium, however, the curve shifted to the right without inhibition of maimal developed tension during hypercapnia compared with rings without endothelium during normocapnia. Hemoglobin abolished the depression of maximal developed tension caused by hypercapnia. The curve shifted to the right in hemoglobin pretreated rings with endothelium during hypercapnia compared with hemoglobin pretreated rings with endothelium during normocapnia. Indomethacin did not alter norepinephrine-induced contractions. These results suggest that endothlium-derived relaxing factor plays an important role in the attenuation of norepinephrine-induced contraction with hypercapnia.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1988-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部