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Study on experimental atrophic gastrits of rats by peroral administration of TCA or MNNG

山口医学 Volume 36 Issue 1 Page 41-49
published_at 1987-02
Title
タウロコール酸(TCA)およびN_メチル-N'-ニトロ-N-ニトロソグアニジン(MNNG)経口投与によるラット実験萎縮性胃炎の検討
Study on experimental atrophic gastrits of rats by peroral administration of TCA or MNNG
Creators Shimada Masakatsu
Source Identifiers
This experment was figured out in order to make sure the etiology of atrophic gastritis. Taurochoria acid (TCA) and N-methy-N'-nitro-N-nitrosoguanidine (MNNG), which are known as reagent inducing atrophic change in the stomach of experimental animals, were adiministrated orally with drinking water into the rats. The rats were sacrificed for histologial study at the several critical points such as 1st, 3rd, 6th, and 10th month. In sonclusion, decrease of parietal cell number, shortening of the lengh of grastric mucosa, increace of fibrosis and infiltlation of inflammatory cells at the interstium were seen characteristically at the glandular stomach of the rats, in which TCA or MNNG was given for 6 or 10 months. Those histokogicak dhanges were as if atrophic gastritis seen in human stomach. Therefore, it seems that this experimental design will be suitable for the study on atrophic gastritis in human.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1987-02
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部