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The Effect of Calcium Antagonist, Diltiazem, on the Relation of Coronary Blood Flow to Regional Myocardial Function

山口医学 Volume 33 Issue 6 Page 465-472
published_at 1984-12
Title
カルシウム拮抗剤, Diltiazem, の冠血流一局所心機能関係に及ぼす影響
The Effect of Calcium Antagonist, Diltiazem, on the Relation of Coronary Blood Flow to Regional Myocardial Function
Creators Miura Toshiro
Source Identifiers
To study the effect of diltiazem (0.3mg/kg) on the relation of coronary blood flow (CBF) to regional myocardial function, left ventricular (LV) pressure, LV wall thickening (%W) by sonomicrometry, and CBF by electromagnetic flowmeter, were measured in 10 anesthetized dogs. CBF was reduced by coronary occluder to induce several degrees of coronary stenosis. The procedures were accompanied by various degrees of regional dysfunction. CBFs during systole (S) and diastole (D) were calculated and D/S ratio was obtained. After diltiazem infusion, heart rate (HR) decreased significantly, but other hemodynamic parameters were not changed CBF-%W relation curve was upward convex, and was shifted upward after diltiazem. D/S ratio increased at mild to moderate reduction of CBF after diltiazem. Thus, diltiazem improved the regional myocardial function by decreasing HR and increasing D/S ratio, which may improve the subendocardial perfusion.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1984-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部