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Smooth Muscle Antibodies and Anti-actin Autoantibody

山口医学 Volume 33 Issue 6 Page 409-418
published_at 1984-12
Title
抗平滑筋抗体と抗アクチン抗体
Smooth Muscle Antibodies and Anti-actin Autoantibody
Creators Nishioka Mikio
Source Identifiers
Human smooth muscle antibodies (SMA) were first detected in sera from patients with chronic active hepatitis. They were also found, usually in low titers, in patients with other liver diseases, viral infections. some malignant diseases, heroin addiction and infertile females. Recent observations of SMA have shown that SMA activity disappears after absorption of SMA by actin, contractile protein and some types of SMA are considered to be an anti-action autoantibody (AAA). This review firstly deals with the incidence and diagnostic significance of AAA in relation to SMA. Occurences of autoantibodies to cytoskeletal proteins are also reported in sera from patients with liver diseases. The second topic is a possible role of AAA in biological studies. Moreover, localization of actin in normal cells and tissues is reported. Finally, this paper describes an induction of autoantibody to actin by immunizing rabbits with actins. A possible mechanism operating in the induction of SMA will be discussed in relation to the termination of natural tolerance to actin.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1984-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部