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Effects of Zopiclone, a New Anxiolytic-Sedative Drug, on the Frontal Midline Theta Activity in Man

山口医学 Volume 32 Issue 5 Page 517-524
published_at 1983-10
Title
新しい睡眠薬zopicloneのFmθに及ぼす影響 : 抗不安薬としての可能性
Effects of Zopiclone, a New Anxiolytic-Sedative Drug, on the Frontal Midline Theta Activity in Man
Creators Mizuki Yasushi
Creators Nishikiori Satoshi
Creators Kajimura Naofumi
Creators Maruo Tadashi
Creators Habu Kensuke
Creators Imaizumi Junichi
Creators Kawasawa Shuhei
Creators Kusunose Yukio
Creators Yamada Michio
Source Identifiers
Creator Keywords
zopiclone diazepam 抗不安作用 脳波 Fmθ
The theta activity which appears on the frontal midline area during performance of mental tasks has been designated as Fmθ. In the present study, a possibility of zopiclone as an anxiolytic was investigated using Fmθ as compared with diazepam. Sixteen male university students were given placebo, diazepam 5 mg, zopiclone 5 mg and 10mg, in a double-blind, cross-over design. EEGs were recorded before and during performance of an arithmetic addition test. This was repeated twice before and 1 hr after the drug administration. Diazepam increased Fmθ markedly but both zopiclone 10mg and placebo slightly and zopiclone 5 mg failed to affect Fmθ. Scores of the state anxiety were reduced most markedly by diazepam and slightly by zopiclone 10 mg but not affected by either zopiclone 5 mg or placebo. The tasks performed were reduced markedly and dose-dependently by zopiclone 5 mg and 10mg, and very slightly by diazepam but slightly increased by placebo. These results suggest that zopiclone possesses rather potent hypnotic effect than anxiolytic, and that Fmθ might be a useful tool to predict the clinical efficacies of anxiolytic drugs in normal humans.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-10
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部