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Gastrointestinal pH Monitoring after Pancreatoduodenectomy

山口医学 Volume 41 Issue 3 Page 227-237
published_at 1992-06
Title
膵頭十二指腸切除後の胃小腸内pHモニタリングに関する研究
Gastrointestinal pH Monitoring after Pancreatoduodenectomy
Creators Nishikawa Masahiro
Source Identifiers
Creator Keywords
pH monitoring 幽門輪温存 膵頭十二指腸切除
Simultaneous gastric amd intestinal pH monitorings were made three times for each patient: before pylorus preserving pancreatoduodenectomy (PPPD), during the acute phase just after PPPD, and during the chronic phase after PPPD with Billroth I -type reconstruction with reference to standard PD. In addition, the effect of H_2-receptor antagonist (famotidine) during the acute phase just after PPPD was examined. On the 3rd postoperative day after PPPD, both intragastric pH and pH3 holding time without famotidine administration were lower than before surgery. During the acute phase just after surgery, both intragastric pH and pH 3 holding time after PPPD with famotidine administration were higher than those without it (P<0.05). The residual gastric pH on the 3rd postoperative day after standard PD was not different from that before surgery. As for the chronic phase, the intragastric pH 3 holding time in the night time after PPPD was significantly lower than that before PPPD (P<0.05). There was no difference in intestinal pH between before and after PPPD. In our series, we detected only one peptic ulcer in PPPD patients (3.7%) and none in standard PD patients. This incidence is lower than that reported elsewhere. Therefore, we conclude that hyperacidity is induced after PPPD, but Billroth I-type reconstruction lowers the incidence of peptic ulcer formation.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1992-06
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部