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Pharmaceutical Study on Antiinflammatory Enzyme Preparations containing Seaprose S

山口医学 Volume 30 Issue 4 Page 491-500
published_at 1981-12
Title
Seaprose S含有消炎酵素製剤の薬剤学的検討
Pharmaceutical Study on Antiinflammatory Enzyme Preparations containing Seaprose S
Creators Koshiro Akira
Creators Uchimi Noriko
Source Identifiers
Pharmaceutical study was carried out on the four kinds of kinds of products of antiinflammatory enzyme, seaprosse S, and the following results were obtained. 1. The pharmaceutical inequivalencies were observed in the enzyme potencies and dissolution profiles. 2. Analysis of valiance on enzyme potencies after accelerated test showed significant differencies regarding the storage conditions (20℃, R.H.75% and 35℃, R.H. 91%), the package (with or without heat sealed package) and the products (A, B, C and D). 3. The newly developed dissolution method, in which the pH of the test fluid is changed simulatively to that of gastrointestinal tract by hidrochloric acid and sodium bicarbonate, was found to be suitable for the evaluation of the dissolution of the products.…
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1981-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部附属病院