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Effects of Enhanced Intrinsic Adenosine by Sympathetic Stimulation on Myoeardial Blood Flow Distribution and Regional Myocardial Function in Flow Limited Canine Model

山口医学 Volume 44 Issue 2 Page 95-104
published_at 1995-04
Title
交感神経刺激による内因性アデノシン産生亢進が心筋内血流分布,局所心筋収縮性に及ぼす影響
Effects of Enhanced Intrinsic Adenosine by Sympathetic Stimulation on Myoeardial Blood Flow Distribution and Regional Myocardial Function in Flow Limited Canine Model
Creators Mikami Shunsuke
Source Identifiers
Creator Keywords
8-スルフォフェニルテオフィリン アデノシン 心筋虚血 交感神経刺激 盗血現象
In patients with critical coronary stenosis, it has been documented that myocardial ischemia continues even after cessation of exercise. To clarify this mechanism, we studied the changes in transmural blood flow distribution and regional myoeardial function in flow limited canine model. In 29 anesthetized dogs, circumflex coronary artery was cannulated and per fused with arterial blood at constant flow rate using a roller pump. Regional wall thiekening (%WT: sonomicrometry) and calculated coronary vascular resistance (CVR) were obtained at control (c), during norepinephrine infusion (NE: 0.3/μg/kg/min, I. C,) and 2 minutes after cessation of NE infusion (R). Regional myocardial blood flow was measured by eolored microspheres at C and R. This protocol was performed with (N=7) and without (n=16) adenosine receptor blockade, 8-sulfophenyl theophylline (8-SPT
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1995-04
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部