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Metabolism and Distribution of Chloral Hydrate in the Rat Stomach

山口医学 Volume 42 Issue 6 Page 371-378
published_at 1993-12
Title
抱水クローラルとその代謝産物のラット胃における局所動態
Metabolism and Distribution of Chloral Hydrate in the Rat Stomach
Creators Murata Tomoko
Source Identifiers
Creator Keywords
抱水クロラール 代謝 胃粘膜
Tissue distribution of chloral hydrate(CH) and its metabolites was investigated using adult Wistar rats, that had received CH intraperitoneally or subcutaneously. The changes in metabolite concentrations in plasma, gastric mucosa, or gastric juice, were as follows. (1) CH appeared in the gastric juice immediately after administration, and then decreased slowly. In gastric mucosa, CH increased over time. (2) Free trichloroethanol (F-TCE) appeared in the gastric juice after the administration of CH. Although F-TCE in the gastric muccsa abruptly decreased 3 h after administration, that in the gastric juice remained elevated for alongtime. (3) Conjugated trichloroethanol (Conj-TCE) appeared into the plasma immediately after the administration of CH. However, the appearance of Conj-TCE in gastric juice was delayed. (4) Appearance of trichloroacetic acid(TCA) in the gastric juice was more delayed than that in the plasma, suggesting difficulties in the transfer of TCA from plasma to gastric juice.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1993-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部