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Role of Heptic Stimulator Substance on Liver regeneration after Portal Branch Ligation (with Special Reference to Significance of the Ligated Hepatic Lobe.)

山口医学 Volume 44 Issue 4 Page 217-222
published_at 1995-08
Title
門脈枝結紮後の肝再生におけるHepatic stimulator substance (HSS)の関与の可能性 : 特に結紮肝の意義
Role of Heptic Stimulator Substance on Liver regeneration after Portal Branch Ligation (with Special Reference to Significance of the Ligated Hepatic Lobe.)
Creators Hiwaki Kazuhisa
Source Identifiers
Creator Keywords
門脈枝結紮 HSS 肝再生 肝萎縮 肝細胞増殖因子
Ligation of a branch of the portal vein results in marked regenerative hypertrophy of the parenchyma of the unligated hepatic lobe, and the ligated lobe shows atrophy. We investigated possible role of hepatic stimulator substance (HSS) produced in the hepatic lobes after portal branch ligation on this regenerative hypertrophy. HSS was extracted from the ligated and the unligated hepatic lobes 24 hours after portal branch ligation in rabbits. Each of the extracts was administrated to mice and hepatic DNA synthesis was compared. The liver treated by the HSS of the ligated lobe showed a significant increase of BrdU labeling index and liver weight in comparison with the liver treated by that of the unligated lobe. These results suggested that HSS produced in ligated lobe plays an important role on regenerative hypertrophy of the unligated lobe after portal branch ligation.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1995-08
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部